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This publication has been prepared by staff members of Microbiology, Virology and Immunology Departments of I.M. Sechenov First Moscow State Medical University, Pirogov Russian National Research Medical University, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Pavlov First Saint Petersburg State Medical University, S.M. Kirov Military Medical Academy, State Medical Universities of Omsk, Orenburg, Chelyabinsk. The textbook is comprised of two volumes, which include 19 chapters, sequentially introducing the issues of general and special microbiology, virology, and immunology. The material presented in both volumes is significantly revised according to the modern science trends and supplemented by illustrations, tables and figures. The textbook is composed in compliance with the approved off icial educational program, and is recommended for the students of the departments of General Medicine, Pediatrics and Preventice Medicine.